Prof. Yehonatan Sharabi graduated from the Faculty of Medicine, Tel Aviv University, Israel, and is the Chief of Medicine at the Sheba Medical Center and an adjunct investigator at the National Institutes of Health, Bethesda, MD, USA. His research focuses on the role of the sympathetic nervous system in blood pressure regulation and its consequences and its involvement in the pathogenesis of Parkinson’s disease – from mechanism to pre-motor diagnosis. Prof Sharabi’s research on the catecholamine system in the development of Parkinson’s disease has led to the emergence of the catechol aldehyde hypothesis with mechanistic insights and therapeutic potential. Moreover, indices of the peripheral sympathetic nervous system were found to be a robust biomarker of prodromal Parkinson’s. They can identify those who would develop the disease among subjects at risk.